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KMID : 0613820080180050631
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Journal of Life Science
2008 Volume.18 No. 5 p.631 ~ p.638
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Effects of Exercise Pre-conditioning on Memory and Cell Proliferation in the Hippocampus of the Rats with Streptozotocin-induced Alzheimer’s disease
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Yoon Jin-Hwan
Lee Hee-Hyuk
Jeong Ill-Gyu
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Abstract
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Physical activity is known to slow the onset and progression of Alzheimer disease. In the present study, we investigated the effects of exercise pre-conditioning on hippocampal cell proliferation and memory in intracerebroventricular streptozotocin-induced Alzheimer’s disease rats. Male (8 weeks old) SpragueDawley rats were used in the present study. Rats in the exercise pre-conditioning group were forced to run on a treadmill for 30 min daily for 14 days before lesioning. Rat model for Alzheimer’s disease was made by injection of streptozotocin (STZ) (1.5 mg/kg) into a bilateral intracerebroventricular (ICV). Passive avoidance test was performed in order to evaluate the memory ability. After memory testing, the rat brains were removed, and 5-bromo-2’-deoxyuridine (BrdU) immunohistochemistry for the detection of cell proliferation were then performed. ICV STZ-injected rats showed a severe deficit in memory associated with decreased cell proliferation in the hippocampus. In contrast, exercise pre-conditioning demonstrated significantly enhanced hippocampal cell proliferation and improved memory performance in ICV STZ-injected rats. These results suggest that exercise pre-conditioning may enhance memory function by increasing cell proliferation in Alzheimer’s type dementia.
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KEYWORD
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Exercise pre-conditioning, intracerebroventricular streptozotocin, memory, cell proliferation, hippocampus
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